Phage Therapy (Biocontrol*): Light and Shade Visit new site : Sellanophagetherapy.blogspot.com: Mycobacterium phages for Mycobacterium ulcerans

"In silico"

From Wikipedia
If the target host* of a phage therapy treatment is not an animal the term "biocontrol" (as in phage-mediated biocontrol of bacteria) is usually employed, rather than "phage therapy".

In silico
From:"Genomics,Proteomics and Clinical Bacteriology",N.Woodford and Alan P.Johnson

Phrase that emphasizes the fact that many molecular biologists spend increasing amounts of their time in front of a computer screen, generating hypotheses that can subsequently be tested and (hopefully) confirmed in the laboratory.

Saturday, 15 October 2011

Mycobacterium phages for Mycobacterium ulcerans

Mycobacterium phage TM4, complete genome

Genome Info:	Features:	BLAST homologs:	Links:	Review Info:
Refseq: NC_003387	Genes: 89	COG	Genome Project	Publications: [1]
GenBank: AF068845	Protein coding: 89	TaxMap	Refseq FTP	Refseq Status: Validated
Length: 52,797 nt	Structural RNAs: None	TaxPlot	GenBank FTP	Seq.Status: Completed
GC Content: 68%	Pseudo genes: None	GenePlot	BLAST	Sequencing center: University of Pittsburgh, Biological Sciences, USA, Pittsburgh
% Coding: 91%	Others: None	gMap	TraceAssembly	Completed: 1999/03/04
Topology: linear	Contigs: None		CDD	Organism Group
Molecule: dsDNA			Other genomes for species:

Mycobacterium phage L5, complete genome

Genome Info:	Features:	BLAST homologs:	Links:	Review Info:
Refseq: NC_001335	Genes: 88	COG	Genome Project	Publications: [2]
GenBank: Z18946	Protein coding: 85	TaxMap	Refseq FTP	Refseq Status: Validated
Length: 52,297 nt	Structural RNAs: 3	TaxPlot	GenBank FTP	Seq.Status: Completed
GC Content: 62%	Pseudo genes: None	GenePlot	BLAST	Sequencing center: Graham F Hatfull Dr, Biological Sciences, University of, Pittsburgh, Department of Biological Sciences, University of, Pittsburgh, Pittsburgh, PA, 15260, USA
% Coding: 87%	Others: 3	gMap	TraceAssembly	Completed: 1993/02/23
Topology: linear	Contigs: None		CDD	Organism Group
Molecule: dsDNA			Other genomes for species:

Mycobacterium phage D29, complete genome

Genome Info:	Features:	BLAST homologs:	Links:	Review Info:
Refseq: NC_001900	Genes: 84	COG	Genome Project	Publications: [1]
GenBank: AF022214	Protein coding: 79	TaxMap	Refseq FTP	Refseq Status: Reviewed
Length: 49,136 nt	Structural RNAs: 5	TaxPlot	GenBank FTP	Seq.Status: Completed
GC Content: 63%	Pseudo genes: None	GenePlot	BLAST	Sequencing center: University of Pittsburgh, Biological Sciences, USA, Pittsburgh
% Coding: 90%	Others: 3	gMap	TraceAssembly	Completed: 1998/06/02
Topology: linear	Contigs: None		CDD	Organism Group
Molecule: dsDNA			Other genomes for species:

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E	Enterococcus faecium	Third most common cause of HCA BSI. Increasing resistance to vancomycin.
S	Staphylococcus aureus (MRSA)	Emerging resistance to current drugs and significant drug toxicities. Lack of oral agents for step-down therapy
K	Klebsiella Escherichia coli K pneumoniae	ESBL-producing organisms increasing in frequency and severity; associated with increasing mortality. K pneumoniae carbapenemases causing severe infections in LTCF. Few active agents; nothing in development
A	Acinetobacter baumannii	Increasing worldwide, recent surge reported in hospitals. Very high mortality. Carbapenem-resistant.
P	Pseudomonas aeruginosa	Increasing P. aeruginosa infections in US and worldwide. Resistant to carbapenems, quinolones, aminoglycosides
E	Enterobacter species	MDR HCA infections increasing; resistance via ESBLs, carbapenemases, and cephalosporinases

E	Enterococcus faecium
S	Staphylococcus aureus (MRSA)	+
K	Klebsiella Escherichia coli K pneumoniae
A	Acinetobacter baumannii	+
P	Pseudomonas aeruginosa	++
E	Enterobacter species

Phage Therapy (Biocontrol*): Light and Shade Visit new site : Sellanophagetherapy.blogspot.com

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"In silico"

Phage Therapy is influenced by:

Saturday, 15 October 2011

Mycobacterium phages for Mycobacterium ulcerans