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"In silico"


From Wikipedia
If the target host* of a phage therapy treatment is not an animal the term "biocontrol" (as in phage-mediated biocontrol of bacteria) is usually employed, rather than "phage therapy".

In silico
From:"Genomics,Proteomics and Clinical Bacteriology",N.Woodford and Alan P.Johnson

Phrase that emphasizes the fact that many molecular biologists spend increasing amounts of their time in front of a computer screen, generating hypotheses that can subsequently be tested and (hopefully) confirmed in the laboratory.


Phage Therapy is influenced by:

Phage therapy is influenced by:

Country : the epidemiological situation is different from country to country in terms of circulating bacteria and bacteriophages. Example: lytic phages from Italy may be no active on the same bacteria (genus and species) isolated from another country and vice versa.
Temporariness
Mutation rate
Phenotypical delay
Phage cocktail

My point of view

Saturday 13 March 2010

Bxz2, D29, L5 and TM4 phages what have in common?





Genome conservation distance matrix

............
.D29................BXZ2..................L5...................TM4

D29..............0................0.563978............0.387869............0.629559

BXZ2........0.563978........... 0..................0.571172........... 0.606553

L5...........0.387869......... 0.571172...............0............... 0.643348

TM4.........0.629559..........0.606553...........0.643348..............0


My question is :

"
What have in common these mycobacteriophages* growing in M.smegmatis and in M.ulcerans ?"

*I am of the opinion that these phages are not usable for Phage therapy but they are capable to furnish to us a lot of details.


































































By Geneious software







In Silico 2D-SDS-PAGE