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"In silico"


From Wikipedia
If the target host* of a phage therapy treatment is not an animal the term "biocontrol" (as in phage-mediated biocontrol of bacteria) is usually employed, rather than "phage therapy".

In silico
From:"Genomics,Proteomics and Clinical Bacteriology",N.Woodford and Alan P.Johnson

Phrase that emphasizes the fact that many molecular biologists spend increasing amounts of their time in front of a computer screen, generating hypotheses that can subsequently be tested and (hopefully) confirmed in the laboratory.


Phage Therapy is influenced by:

Phage therapy is influenced by:

Country : the epidemiological situation is different from country to country in terms of circulating bacteria and bacteriophages. Example: lytic phages from Italy may be no active on the same bacteria (genus and species) isolated from another country and vice versa.
Temporariness
Mutation rate
Phenotypical delay
Phage cocktail

My point of view

Saturday 19 June 2010

Commercial phage preparations





PHAGE APPLICATIONS
From Eliava Institute documents
:




Documents : year 1984 and year 2005
(or 07? )


Phage preparations













Staphylococcus aureus phage Sb-1


The phage Sb-1
is used for intravenous bacteriophage preparation.





Pseudomonas aeuriginosa phages



Phage Cocktail





Phage parameters



Table






MICROGEN (Russian company)






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STAPHYLOCOCCUS BACTERIOPHAGE

(liquid preparation)It is a highly efficient therapeutic and prophylactic agent against antibiotic-resistant staphylococcus strains to treat all kinds of skin, mucous membrane and inner organs` lesions caused by staphylococci, i.e. furunculosis, carbunculosis, hydroadenitis, abscesses, purulent wounds, pleurisy, bursitis, thermal burns, chronic osteomyelitis, phlegmons, tenosynovitis, mastitis, cystitis, cholecystitis, deeply infil-trated sycosis complicated by staphylococcus abscess, tonsillitis, enterocolitis.

The preparation is highly efficient in the cases of enteric disease, dysbacteriosis. Its therapeutic effect is not less than 95 %.
Staphylococcus bacteriophage does not affect the normal intestinal flora, causes no adverse reactions, is harmless for children and pregnant women.
Storage time: 18 months at 4-10 C°.
Supplied in ampules, 10 ml.






Question mark

Are Phages a valid alternative to Antibiotic prophylaxis in surgery ?

Two point of view:

1-From Western countries:
Scottish Intercollegiate Guidelines Network (Guideline)

2-From EX-SOVIET countries: Watch the film-clip .


From
: Pyobacteriophage liquid

"During gastrointestinal tract surgery and peritonitis preparation is introduced in quantity of 100 ml, after that wound is sewed and bacteriophage is introduced by drainage once a day during 3 – 4 days"


To pay attention when the surgeon gives the preparation with Phages.