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"In silico"


From Wikipedia
If the target host* of a phage therapy treatment is not an animal the term "biocontrol" (as in phage-mediated biocontrol of bacteria) is usually employed, rather than "phage therapy".

In silico
From:"Genomics,Proteomics and Clinical Bacteriology",N.Woodford and Alan P.Johnson

Phrase that emphasizes the fact that many molecular biologists spend increasing amounts of their time in front of a computer screen, generating hypotheses that can subsequently be tested and (hopefully) confirmed in the laboratory.


Phage Therapy is influenced by:

Phage therapy is influenced by:

Country : the epidemiological situation is different from country to country in terms of circulating bacteria and bacteriophages. Example: lytic phages from Italy may be no active on the same bacteria (genus and species) isolated from another country and vice versa.
Temporariness
Mutation rate
Phenotypical delay
Phage cocktail

My point of view

Saturday, 26 June 2010

Marketing point of view on Phage therapy



Before to evaluate this aspect we must know the situation by different points that I reassume here:

1°- the scientific meeting organization trend where topics about phage therapy are present.

2°- if there are some business analysis studies about potential Phage therapy business in the Net.

3°- the growth of Phage therapy companies.


By these information we start with a comparison and we verify if between "theory and practice "there is a distance.



The First point: the scientific meeting organization trend where topics about phage therapy are present.


The answer is positive.





A Literature Review of the Practical Application of Bacteriophage Research by Nina Chanishvili, Eliava Institute of Bacteriophage, Microbiology and Virology, Tbilisi, Georgia


The review contains the following chapters:


Introduction

Chapter 1. Animal studies

Chapter 2. Phage Therapy in Dermatology

Chapter 3. Phage Therapy in Surgery and Wound Treatment

Chapter 4. Phage Therapy against Intestinal Infections

Chapter 5. Phage Therapy in Urology

Chapter 6. Phage Therapy in Gynecology

Chapter 7. Phage Therapy in Ophthalmology

Chapter 8. Combined Phage- and Sero- Therapy. (Vaccination). Development of Phage-Vaccines

Chapter 9. Combined Use of Phages and Antibiotics

Chapter 10. Experience of Prophylactic “Phaging” or Phage Prophylaxis

Chapter 11. Immune Response to Phage Therapy

Chapter 12. Phage Therapy against Septic Infections

Chapter 13. Phages in Veterinary

Chapter 14. Use of Phage Treatment for Plant Protection

Chapter 15. Environmental Role of Bacteriophages

Chapter 16. Phages Potentially Applicable against Bioterrorism

Chapter 17. Methodology for Manufacturing of Bacteriophages in Industrial Scale


From the review we have indications about the interested
areas.


From this document we get three information about the application areas :







" Learn how to turn a phage into a the various potentials of phages in the diagnosis (1) and management of marketable product bacterial contamination (2)".

Phage therapy as a personalized medicine combining diagnostic and phage therapy(3).



The Second point: if there are some business analysis studies about potential Phage therapy business in the Net.


The answer is positive.




The third point: the growth of Phage therapy companies.

After
a Boom ( about ten years ago) how many Phage therapy companies are surviving now? What are the products?


The answer is neutral.

Novophage





Biocontrol Limited

Biocontrol News

Mycodax Corporation


Intralytix




Intralytix is more active than other companies.





Conclusion:

At moment
the Market is open only for phages applied to Food safety,Animal health and Plant health.

At moment the Market is not open for phages applied to Human health
( see Phage therapy as a personalized medicine combining diagnostic and phage therapy(3)).


Food Safety Environmental Sanitation Veterinary Applications Human Therapeutics


Bacteriophage biocontrol in animals and meat products