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"In silico"


From Wikipedia
If the target host* of a phage therapy treatment is not an animal the term "biocontrol" (as in phage-mediated biocontrol of bacteria) is usually employed, rather than "phage therapy".

In silico
From:"Genomics,Proteomics and Clinical Bacteriology",N.Woodford and Alan P.Johnson

Phrase that emphasizes the fact that many molecular biologists spend increasing amounts of their time in front of a computer screen, generating hypotheses that can subsequently be tested and (hopefully) confirmed in the laboratory.


Phage Therapy is influenced by:

Phage therapy is influenced by:

Country : the epidemiological situation is different from country to country in terms of circulating bacteria and bacteriophages. Example: lytic phages from Italy may be no active on the same bacteria (genus and species) isolated from another country and vice versa.
Temporariness
Mutation rate
Phenotypical delay
Phage cocktail

My point of view

Wednesday, 9 June 2010

Pseudomonas syringae pv. aesculi attacks horse chestnut Aesculus hippocastanum causing Bleeding Canker of Horse Chestnut.



Good News
!

There is a real interest about Phage therapy in agriculture and for this reason some Universities are starting with specific projects, like this from
School of Biological Sciences, University of Reading
.



The School of Biological Sciences at the University of Reading covers many aspects of modern biology. It has three divisions: Environmental Biology, Biomolecular Sciences and Applied Statistics. We comprise about 50 full-time academic staff with 200 other staff and about 180 research students. We are very well equipped and have excellent links with other University units and departments such as the Biocentre - concentrating on structural biology and post genomic technologies - the Centre for Advanced Microscopy, and the Centre for Agro-Ecological Research. Link


From Forestry commission(UK)
From Wikipedia
From Microbe Wikipedia

At moment there are only 3 pathovars
of Pseudomonas siringae completely sequenced:

Pseudomonas syringae pv. phaseolicola 1448A
Pseudomonas syringae pv. syringae B728a
Pseudomonas syringae pv. tomato str. DC3000


This is my tiny contribution:

Genome alignment
by Mauve software:


and Dot plot by Gepard software: