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"In silico"


From Wikipedia
If the target host* of a phage therapy treatment is not an animal the term "biocontrol" (as in phage-mediated biocontrol of bacteria) is usually employed, rather than "phage therapy".

In silico
From:"Genomics,Proteomics and Clinical Bacteriology",N.Woodford and Alan P.Johnson

Phrase that emphasizes the fact that many molecular biologists spend increasing amounts of their time in front of a computer screen, generating hypotheses that can subsequently be tested and (hopefully) confirmed in the laboratory.


Phage Therapy is influenced by:

Phage therapy is influenced by:

Country : the epidemiological situation is different from country to country in terms of circulating bacteria and bacteriophages. Example: lytic phages from Italy may be no active on the same bacteria (genus and species) isolated from another country and vice versa.
Temporariness
Mutation rate
Phenotypical delay
Phage cocktail

My point of view

Thursday 27 May 2010

M.smegmatis Mpr protein alignment with M.ulcerans and M.marinum proteins




1-By BugView software (open source) I have compared Mpr protein from M. smegmatis str. MC2 155 with genomes of M.ulcerans Agy99 and M.marinum M.

2-By Geneious software ( commercial software) I have studied the proteins that have a correlation with Mpr protein:

MUL 3786- 4227021:4227812 proline rich membrane protein

MMAR_3854 - 4791940: 4792731 proline rich membrane protein




Alignments




By Gepard software (open source) : Dot plot