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"In silico"


From Wikipedia
If the target host* of a phage therapy treatment is not an animal the term "biocontrol" (as in phage-mediated biocontrol of bacteria) is usually employed, rather than "phage therapy".

In silico
From:"Genomics,Proteomics and Clinical Bacteriology",N.Woodford and Alan P.Johnson

Phrase that emphasizes the fact that many molecular biologists spend increasing amounts of their time in front of a computer screen, generating hypotheses that can subsequently be tested and (hopefully) confirmed in the laboratory.


Phage Therapy is influenced by:

Phage therapy is influenced by:

Country : the epidemiological situation is different from country to country in terms of circulating bacteria and bacteriophages. Example: lytic phages from Italy may be no active on the same bacteria (genus and species) isolated from another country and vice versa.
Temporariness
Mutation rate
Phenotypical delay
Phage cocktail

My point of view

Sunday 13 February 2011

KEGG Mycobacterium ulcerans

KEGG Mycobacterium ulcerans

Search genes:


Genome information

T numberT00435
Org codemul
AliasesM.ulcerans, MYCUA, 362242
Full nameMycobacterium ulcerans
DefinitionMycobacterium ulcerans Agy99
Annotationmanual
TaxonomyTAX: 362242
LineageBacteria; Actinobacteria; Actinobacteridae;
Actinomycetales; Corynebacterineae;
Mycobacteriaceae; Mycobacterium
Data sourceRefSeq (Project:16230)
Original DBPasteur
KeywordsHuman pathogen
DiseaseH00285 Blau syndrome
CommentIsolated from an ulcerative lesion on the right elbow
of a female patient from the Ga district of
Ghana in 1999
ChromosomeCircular
SequenceRS: NC_008611
Length5631606
PlasmidpMUM001; Circular
SequenceRS: NC_005916
Length174155
StatisticsNumber of nucleotides: 5805761
Number of protein genes: 4241
Number of RNA genes: 50
ReferencePMID: 17210928
AuthorsStinear TP, et al.
TitleReductive evolution and niche adaptation inferred
from the genome of Mycobacterium ulcerans,
the causative agent of Buruli ulcer.
JournalGenome Res 17:192-200 (2007)