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"In silico"


From Wikipedia
If the target host* of a phage therapy treatment is not an animal the term "biocontrol" (as in phage-mediated biocontrol of bacteria) is usually employed, rather than "phage therapy".

In silico
From:"Genomics,Proteomics and Clinical Bacteriology",N.Woodford and Alan P.Johnson

Phrase that emphasizes the fact that many molecular biologists spend increasing amounts of their time in front of a computer screen, generating hypotheses that can subsequently be tested and (hopefully) confirmed in the laboratory.


Phage Therapy is influenced by:

Phage therapy is influenced by:

Country : the epidemiological situation is different from country to country in terms of circulating bacteria and bacteriophages. Example: lytic phages from Italy may be no active on the same bacteria (genus and species) isolated from another country and vice versa.
Temporariness
Mutation rate
Phenotypical delay
Phage cocktail

My point of view

Sunday, 30 January 2011

Journal dedicated to all aspects of Bacteriophage Research


Volume 1, Issue 1
January/February 2011
View covers archive


EDITOR'S CORNER
*
On an invisible microbe antagonistic to dysentery bacilli. Note by M. F. d’Herelle, presented by M. Roux. Comptes Rendus Academie des Sciences 1917; 165:373–5


BASIC RESEARCH PAPERS
*
Genomic and molecular analysis of phage CMP1 from Clavibacter michiganensis subspecies michiganensis
Open Access Article
Johannes Wittmann, Karl-Heinz Gartemann, Rudolf Eichenlaub and Brigitte Dreiseikelmann
*
Naturally resident and exogenously applied T4-like and T5-like bacteriophages can reduce Escherichia coli O157:H7 levels in sheep guts
Open Access Article
Raul R. Raya, Rebecca A. Oot, Ben Moore-Maley, Serena Wieland, Todd R. Callaway, Elizabeth Kutter and Andrew D. Brabban
*
The lysis cassette of bacteriophage фKMV encodes a signal-arrest-release endolysin and a pinholin
Open Access Article
Yves Briers, Liesbet M. Peeters, Guido Volckaert and Rob Lavigne

REVIEW
*
Phages in nature
Martha R.J. Clokie, Andrew D. Millard, Andrey V. Letarov and Shaun Heaphy

VIEWS AND COMMENTARIES
*
Lysis from without
Open Access Article
Stephen T. Abedon
*
In the beginning...
Open Access Article
William C. Summers
*
Phage or phages
Open Access Article
Hans-Wolfgang Ackermann


Pros and cons of phage therapy


Volume 1, Issue 2 March/April 2011
Catherine Loc-Carrillo and Stephen T. Abedon