The six bacteriophage strains (which were deposited at the National Collection of Industrial and Marine Bacteria, 23 St Machar Drive, Aberdeen, AB24 3RY, Scotland, UK on 24 June 2003) :
Reference NCIMB Deposit
1- BC-BP-01 NCIMB 41174
2- BC-BP-02 NCIMB 41175
3-BC-BP-03 NCIMB 41176
4- BC-BP-04 NCIMB 41177
5- BC-BP-05 NCIMB 41178
6- BC-BP-06 NCIMB 41179
Veterinary Field Trial
A combined preparation of six bacteriophages was named BioVet-PA, and was authorized for trial in dogs with such infection by the Veterinary Medicines Directorate of the United Kingdom in November 2003.
Conduct of the Trial
BioVet-PA was stored at -80° C. Immediately prior to administration, the product was thawed and warmed in the hand 0.2 ml (containing 1x10^5 pfu by original titration of each of the 6 bacteriophages) was administered drop-wise using a sterile 1 ml capacity syringe into the ear. Ear condition and microbiology was assessed at 2 days post-administration.
Human Clinical Trial
This study investigated the efficacy and safety of BioPhage-PA, a mixture of six Pseudomonas aeruginosa bacteriophages of the same types as those tested as BioVet-PA in the veterinary field trial.
BIOPHAGE-PA
