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"In silico"


From Wikipedia
If the target host* of a phage therapy treatment is not an animal the term "biocontrol" (as in phage-mediated biocontrol of bacteria) is usually employed, rather than "phage therapy".

In silico
From:"Genomics,Proteomics and Clinical Bacteriology",N.Woodford and Alan P.Johnson

Phrase that emphasizes the fact that many molecular biologists spend increasing amounts of their time in front of a computer screen, generating hypotheses that can subsequently be tested and (hopefully) confirmed in the laboratory.


Phage Therapy is influenced by:

Phage therapy is influenced by:

Country : the epidemiological situation is different from country to country in terms of circulating bacteria and bacteriophages. Example: lytic phages from Italy may be no active on the same bacteria (genus and species) isolated from another country and vice versa.
Temporariness
Mutation rate
Phenotypical delay
Phage cocktail

My point of view

Tuesday, 13 July 2010

1°- Is Cystic fibrosis disease a potential target for Biocontrol?

When we explore a disease for evaluating if it is a potential target for a therapeutic treatment by Biocontrol we must study before the disease from various points of view.

From:

MedlinePlus

A crude description:

"Cystic fibrosis (CF) is an inherited disease of the mucus and sweat glands. It affects mostly your lungs, pancreas, liver, intestines, sinuses and sex organs. CF causes your mucus to be thick and sticky. The mucus clogs the lungs, causing breathing problems and making it easy for bacteria to grow. This can lead to problems such as repeated lung infections and lung damage.
The symptoms and severity of CF vary widely. Some people have serious problems from birth. Others have a milder version of the disease that doesn't show up until they are teens or young adults.
Although there is no cure for CF, treatments have improved greatly in recent years. Until the 1980s, most deaths from CF occurred in children and teenagers. Today, with improved treatments, people with CF live, on average, to be more than 35 years old".


Wikipedia :
Cystic Fibrosis


Genomics.energy.gov

Merck manual home edition

Merck manual

Organizations and Support Groups

Cystic Fibrosis Foundation

Cystic Fibrosis Research, Inc.

Canadian Cystic Fibrosis Foundation

Cystic Fibrosis World Wide

Cystic-L Cystic Fibrosis Information and Support


Diagnostic Testing

Cystic Fibrosis Testing - From GeneCare Medical Genetics Center

Cystic Fibrosis Carrier Testing: - Publication created by the Michigan State University DNA Diagnostic Program

Cystic Fibrosis Research Directions - NIH Publication 97-4200

Access to Health (NOAH)


Clinical Trials

Cystic Fibrosis Studies - Listed at clinicaltrials.gov


Other Cystic Fibrosis Resources


MedlinePlus Entry for Cystic Fibrosis

NCBI Genes and Disease Entry for Cystic Fibrosis

Johns Hopkins Medicine: Cystic Fibrosis





DIFFICULT TO TREAT MICROBES

"
Help in Fighting Resistant Bacteria

Columbia College of Physicians and Surgeons (Columbia Medical School) in New York has a screening program for multi-resistant bacteria. If I understand the procedure correctly, your doctor either calls them with the result of your sputum culture, or sends a sample of sputum to Columbia for growth in their labs. They put it through a series of sensitivity tests using single and multiple drugs, to test not just sensitivity to the individual drugs but also to look for the most effecient paring of drugs (those that would act synergistically to overcome resistance). The report they give back is quite detailed and give recommendations on various drug(s). They tested some two dozen or so. It takes a couple of weeks to get the results".