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"In silico"


From Wikipedia
If the target host* of a phage therapy treatment is not an animal the term "biocontrol" (as in phage-mediated biocontrol of bacteria) is usually employed, rather than "phage therapy".

In silico
From:"Genomics,Proteomics and Clinical Bacteriology",N.Woodford and Alan P.Johnson

Phrase that emphasizes the fact that many molecular biologists spend increasing amounts of their time in front of a computer screen, generating hypotheses that can subsequently be tested and (hopefully) confirmed in the laboratory.


Phage Therapy is influenced by:

Phage therapy is influenced by:

Country : the epidemiological situation is different from country to country in terms of circulating bacteria and bacteriophages. Example: lytic phages from Italy may be no active on the same bacteria (genus and species) isolated from another country and vice versa.
Temporariness
Mutation rate
Phenotypical delay
Phage cocktail

My point of view

Saturday, 26 December 2009

Nestlé Nutrition Corporate is starting in Phage Therapy trials

Antibacterial Treatment Against Diarrhea in Oral Rehydration Solution
(by T4 phage)

Randomized, Double Blind Placebo-controlled Studies to Evaluate the Effect of an Orally-fed Escherichia Coli (E. Coli) Phage in the Management of ETEC and EPEC Induced Diarrhea in Children.

This study hopes to demonstrate the potentials of a new form of therapy for childhood diarrhea, a major cause of morbidity and deaths in Bangladesh and other developing countries, and thus a priority for improving child health.




Scientific works:


T4 phages against Escherichia coli diarrhea: Potential and problems
Nestle´ Research Centre, CH-1000 Lausanne 26 Vers-chez-les-Blanc, Switzerland

Phage therapy: the Escherichia coli experience
Harald Brüssow
Nestle´ Research Centre, CH-1000 Lausanne 26 Vers-chez-les-Blanc, Switzerland


Human Volunteers Receiving Escherichia coli Phage T4 Orally:
a Safety Test of Phage Therapy

Anne Bruttin and Harald
Brüssow,
Nestle´ Research Center, Nestec Ltd., Vers-chez-les-Blanc, CH-1000 Lausanne 26, Switzerland