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"In silico"


From Wikipedia
If the target host* of a phage therapy treatment is not an animal the term "biocontrol" (as in phage-mediated biocontrol of bacteria) is usually employed, rather than "phage therapy".

In silico
From:"Genomics,Proteomics and Clinical Bacteriology",N.Woodford and Alan P.Johnson

Phrase that emphasizes the fact that many molecular biologists spend increasing amounts of their time in front of a computer screen, generating hypotheses that can subsequently be tested and (hopefully) confirmed in the laboratory.


Phage Therapy is influenced by:

Phage therapy is influenced by:

Country : the epidemiological situation is different from country to country in terms of circulating bacteria and bacteriophages. Example: lytic phages from Italy may be no active on the same bacteria (genus and species) isolated from another country and vice versa.
Temporariness
Mutation rate
Phenotypical delay
Phage cocktail

My point of view

Tuesday 27 January 2009

Some Conclusions

Partial Conclusions


1-
Suppurative Bacterial Infections, caused by multidrug-resistant bacteria are responsive to treatment by Phage Therapy.

2-
Bacteria involved are: Methicillin Resistant Staphylococcus aureus, Streptococcus spp., Enterococcus spp., E. coli, Proteus spp., Klebsiella pneumoniae, Pseudomonas aeruginosa.

3-
Treatable Infections are :

Septicemia; Purulent otitis media; Purulent meningitis;Varicose ulcers of lower extremities; Mucopurulent chronic Bronchitis, Laryngitis, Rhinitis; Bronchopneumonia;Empyema;Pleuritis with fistula; Suppurative peritonitis;Urinary tract infections; Furunculosis ; Decubitus with infection;Pyogenic arthritis and Myositis; Osteomyelitis of the Long Bones; Suppurative Osteitis after Bone Fractures;Pyogenic Infections of Burns;Pyogenic Postoperative Infection:Chronic Suppurative Fistulas;Suppurative Sinusitis;Purulent Mastitis.






4- The
Body Area where a Bacterial Infection is active has a lot of influence on Phage Therapy results:

Efficacy value (++++++)
-
Infections in which Phage Administration is by external applications only ( example Wounds, Burns).

Efficacy value (+?)
-
Infections in which Phage Administration is orally.