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"In silico"


From Wikipedia
If the target host* of a phage therapy treatment is not an animal the term "biocontrol" (as in phage-mediated biocontrol of bacteria) is usually employed, rather than "phage therapy".

In silico
From:"Genomics,Proteomics and Clinical Bacteriology",N.Woodford and Alan P.Johnson

Phrase that emphasizes the fact that many molecular biologists spend increasing amounts of their time in front of a computer screen, generating hypotheses that can subsequently be tested and (hopefully) confirmed in the laboratory.


Phage Therapy is influenced by:

Phage therapy is influenced by:

Country : the epidemiological situation is different from country to country in terms of circulating bacteria and bacteriophages. Example: lytic phages from Italy may be no active on the same bacteria (genus and species) isolated from another country and vice versa.
Temporariness
Mutation rate
Phenotypical delay
Phage cocktail

My point of view

Monday, 26 January 2009

Phage Therapy from Polish Academy of Sciences Institute of Immunology and Experimental Therapy




WROCLAW Phage Research

"Since
1980 the specific Bacteriophages have been used in our Laboratory for the treatment of over 1500 patients with Suppurative Bacterial Infections, in which a routine antibiotic therapy failed. The Results obtained so far showed that Phage Therapy is Safe and Highly Effective (the majority of patients were cured).

To make a note


Phage Therapy may be applied to all Patients from whom isolated Bacterial Strains show full sensitivity to specific Phages. Of particular importance is that two pathogens: Staphylococcus aureus and Pseudomonas aeruginosa, which most frequently cause infections, were found to be sensitive to specific Phages in more than 80% of cases.

Our Laboratory possesses over
300 specific Bacteriophage strains active against Staphylococcus aureus, Escherichia, Klebsiella, Enterobacter, Proteus and Pseudomonas.

To make a note

We offer:

* isolation and identification of
Bacterial Strains from the specimens of patients
* determination
of Sensitivity of the Isolated Strains to specific Bacteriophages
* preparation
of Phage Lysates for a Therapeutic Treatment


To make a note

The indications of the range of Phage Therapy are as follows:

Postoperative infections
Mucopurulent bronchitis
Furunculosis
Otitis media
Sinusitis
Abscesses cutis and Decubitus Ulcer
Pyogenic arthritis
Osteomyelitis
Suppurative Infections after Injuries of Soft Tissue, such as Contusions, Burns. Pyogenic Infection after Bone fractures
Chronic Infections of the Urinary Tract
Bacterial Prostatitis.


The majority of patients were cured

The Center for Phage Therapy accepts Patients with Drug-Resistant Bacterial Infections."