Cell wall
Antigen 85LAMMmaA4PDIMPcaACellular metabolismFadD33Isocitrate lyaseLipFNitrate reductasePanC/PanDHeat-shock proteinHspXIron uptakeMycobactinMagnesium uptakeMgtCRegulationDevRSHspRIdeRMprABPhoPRelASigASigESigFSigHWhiB3Secreted proteinsESAT-6/CFP-10Secretion systemESX-1ESX-5Stress proteinAhpCKatGSodASodCToxinPhospholipase CUnclassifiedErpHbhAPE/PE-PGRSMycobacterium ulcerans Agy99
| Virulence factors | Related genes | M. ulcerans Agy99 |
| chromosome NC_008611 (5631606 bp) | ||
| Amino acid and purine metabolism | ||
| Glutamine synthesis | glnA1 | MUL_1340 |
| Leucine synthesis | leuD | MUL_1969 |
| Lysine synthesis | lysA | MUL_3971 |
| Proline synthesis | proC | MUL_4570 |
| Purine synthesis | purC | MUL_0497 |
| Tryptophan synthesis | trpD | MUL_3549 |
| Anaerobic respiration | ||
| Fused nitrate reductase | narX | |
| Nitrate reductase | narG | |
| narH | ||
| narJ | ||
| narI | ||
| Nitrate/nitrite transporter | narK2 | |
| Anti-apoptosis factor | ||
| NuoG | nuoG | MUL_2465 |
| Cell surface components | ||
| Exported repetitive protein | erp | MUL_4994 |
| Heparin-binding hemagglutinin | hbhA | MUL_4543 |
| Laminin-binding protein LBP21/Hlp | - | |
| Methyltransferase | mma4 | MUL_0729 |
| Mycolic acid trans-cyclopropane synthetase | cmaA2 | MUL_4575 |
| PDIM (phthiocerol dimycocerosate) and PGL (phenolic glycolipid) biosynthesis and transport | fadD26 | MUL_2020 |
| fadD28 | MUL_2008 | |
| ppsA | MUL_2019 | |
| ppsB | MUL_2018 | |
| ppsC | MUL_2017 | |
| ppsD | MUL_2016 | |
| ppsE | MUL_2015 | |
| papA5 | MUL_2011 | |
| mas | MUL_2010 | |
| mmpL7 | MUL_2007 | |
| ddrA | MUL_2014 | |
| ddrB | MUL_2013 | |
| drrC | MUL_2012 | |
| pks15/1 | MUL_2005 | |
| - | ||
| - | ||
| - | ||
| - | MUL_2377 | |
| - | ||
| Proximal cyclopropane synthase of alpha mycolates | pcaA | MUL_4539 |
| Sulfolipid-1 biosynthesis and transport | stf0 | |
| papA2 | ||
| papA1 | ||
| pks2 | ||
| mmpL8 | ||
| Lipid and fatty acid metabolism | ||
| FAS-II | kasB | MUL_1303 |
| Isocitrate lyase | icl | MUL_4536 |
| Lipase | lipF | |
| Lipid phosphatase | sapM | MUL_2676 |
| Pantothenate synthesis | panC | MUL_4184 |
| panD | MUL_4183 | |
| Phospholipases C | plcA | |
| plcB | MUL_2799 | |
| plcC | ||
| plcD | ||
| Mammalian cell entry (mce) operons | ||
| Mce1 | mce1A | MUL_1062 |
| mce1B | MUL_1063 | |
| mce1C | MUL_1064 | |
| mce1D | MUL_1065 | |
| mce1E | MUL_1066 | |
| mce1F | MUL_1067 | |
| Mce2 | mce2A | MUL_0415 |
| mce2B | ||
| mce2C | ||
| mce2D | ||
| mce2E | ||
| mce2F | ||
| Mce3 | mce3A | MUL_3918 |
| mce3B | MUL_3919 | |
| mce3C | MUL_3920 | |
| mce3D | MUL_3921 | |
| mce3E | MUL_3922 | |
| mce3F | MUL_3923 | |
| Mce4 | mce4A | MUL_4062 |
| mce4B | MUL_4061 | |
| mce4C | MUL_4060 | |
| mce4D | MUL_4059 | |
| mce4E | MUL_4058 | |
| mce4F | MUL_4057 | |
| Mce5 | mce5A | MUL_3796 |
| mce5B | MUL_3797 | |
| mce5C | MUL_3798 | |
| mce5D | ||
| mce5E | MUL_3800 | |
| mce5F | MUL_3801 | |
| Mce6 | mce6A | MUL_4919 |
| mce6B | MUL_4918 | |
| mce6C | MUL_4917 | |
| mce6D | MUL_4916 | |
| mce6E | MUL_4915 | |
| mce6F | MUL_4914 | |
| Mce7 | mce7A | |
| mce7B | ||
| mce7C | ||
| mce7D | ||
| mce7E | ||
| mce7F | ||
| Mce8 | mce8A | |
| mce8B | ||
| mce8C | ||
| mce8D | ||
| mce8E | ||
| mce8F | ||
| Mce9 | mce9A | |
| mce9B | ||
| mce9C | ||
| mce9D | ||
| mce9E | ||
| mce9F | ||
| Metal uptake | ||
| ABC transporter | irtA | MUL_3902 |
| irtB | MUL_3901 | |
| Exochelin (smegmatis) | - | |
| Iron-dependent regulator | ideR | MUL_3351 |
| Magnesium transport | mgtC | MUL_3069 |
| Mycobactin | mbtH | MUL_3639 |
| mbtG | MUL_3640 | |
| mbtF | MUL_3633 | |
| mbtE | MUL_3634 | |
| mbtD | MUL_3638 | |
| mbtC | MUL_3637 | |
| mbtB | MUL_3632 | |
| mbtA | MUL_3641 | |
| mbtJ | MUL_3642 | |
| mbtI | MUL_3648 | |
| Regulation | ||
| (p)ppGpp synthesis and hydrolysis | relA | MUL_1729 |
| DevR/S | devR/dosR | MUL_2423 |
| devS | MUL_2422 | |
| MprA/B | mprA | MUL_4701 |
| mprB | MUL_4700 | |
| PhoP/R | phoP | MUL_0463 |
| phoR | MUL_0464 | |
| PrrA/B | prrA | MUL_0248 |
| prrB | MUL_0249 | |
| Sigma A | sigA/rpoV | MUL_3341 |
| Sigma E | sigE | MUL_4519 |
| Sigma F | sigF | MUL_2640 |
| Sigma H | sigH | MUL_2545 |
| Sigma M | sigM | MUL_5064 |
| WhiB3 | whiB3 | MUL_0895 |
| Secreted proteins | ||
| 19-kD protein | lpqH | MUL_4389 |
| Alpha-crystallin | hspX | |
| Antigen 85 complex | fbpA | MUL_4987 |
| fbpB | MUL_2970 | |
| fbpC | MUL_4793 | |
| Enhanced intracellular survival protein | eis | |
| Protein kinase G | pknG | MUL_2810 |
| Secretion system | ||
| Accessory secretion factor | secA2 | MUL_3040 |
| ESX-1 (ESAT-6 system-1) | - | |
| - | ||
| - | ||
| - | ||
| PE35 | ||
| - | ||
| - | ||
| - | ||
| mycP1 | ||
| - | ||
| ESX-1 substrates | esxA | |
| esxB | ||
| - | ||
| espA | ||
| espB | ||
| ESX-5 secretion system | - | MUL_3077 |
| - | MUL_3078 | |
| mycP5 | MUL_3079 | |
| - | MUL_3080 | |
| - | MUL_3081 | |
| esxN | MUL_3082 | |
| esxM | MUL_3083 | |
| - | MUL_3092 | |
| - | MUL_3092 | |
| - | MUL_3093 | |
| ESX-5 substrates | PPE41 | |
| Stress adaptation | ||
| AhpC | ahpC | MUL_2999 |
| Catalase-peroxidase | katG | MUL_2190 |
| Cu,Zn superoxide dismutase | sodC | MUL_1379 |
| Iron-cofactored SOD | sodA | MUL_5018 |
