Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study
Characterization of a New Metallo-β-Lactamase Gene, blaNDM-1, and a Novel Erythromycin Esterase Gene Carried on a Unique Genetic Structure in Klebsiella pneumoniae Sequence Type 14 from India
National Resistance Alert 3 addendum in UK:
*These organisms mostly are resistant to ALL antibiotics except polymyxins and, less consistently, tigecycline.
From Wikipedia
The following antibiotics are inactivated by the enzyme ND Metallo-beta-lactamase (NDM-1):
- 1 Penicillinase
- 2 Classification of Beta Lactamase
- 3 Resistance in Gram-negative bacteria
- 3.1 Extended-spectrum beta-lactamase (ESBL)
- 3.2 Inhibitor-resistant β-lactamases
- 3.3 AmpC-type β-lactamases (Class C)
- 3.4 Carbapenemases
- 3.4.1 IMP-type carbapenemases (one of the metallo-β-lactamases)
- 3.4.2 VIM (Verona integron-encoded metallo-β-lactamase)
- 3.4.3 OXA (oxacillinase) group of β-lactamases (Class D)
- 3.4.4 KPC (K. pneumoniae carbapenemase) (Class A)
- 3.4.5 CMY (Class C)
- 3.4.6 SME, IMI, NMC and CcrA
- 3.4.7 NDM-1 (New Delhi metallo-β-lactamase)
- 4 Treatment of ESBL/AmpC/carbapenemases