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"In silico"


 From Wikipedia
If the target host* of a phage therapy treatment is not an animal the term "biocontrol" (as in phage-mediated biocontrol of bacteria) is usually employed, rather than "phage therapy".

In silico
From:"Genomics,Proteomics and Clinical Bacteriology",N.Woodford and Alan P.Johnson

Phrase that emphasizes the fact that many molecular biologists spend increasing amounts of their time in front of a computer screen, generating hypotheses that can subsequently be tested and (hopefully) confirmed in the laboratory.


Phage Therapy is influenced by:

Phage therapy is influenced by:

Country : the epidemiological situation is different from country to country in terms of circulating bacteria and bacteriophages. Example: lytic phages from Italy may be no active on the same bacteria (genus and species) isolated from another country and vice versa.
Temporariness
 Mutation rate
Phenotypical delay
Phage cocktail

My point of view

Thursday, 4 March 2010

Frequency rate between Lytic phages and Lysogenic phages

The questions are:


Are there more Lytic phages or more Lysogenic phages for example in Acinetobacter baumannii or in Mycobacterium ulcerans or in other genera ?

Are there Lytic Phages or are there not Lytic Phages for all genera?

What is the frequency rate between Lytic phages (%?) and Lysogenic phages (%?) capable to growth in each of these Bacteria ?


Lytic phages> Lysogenic phages ?
or
 Lysogenic phages >Lytic phages ?
or
no Lytic phages but only Lysogenic phages ?


From the book " BACTERIOPHAGES" the probable answer: "Lysogenic bacteria are very common in nature and probably constitute the principal reservoir of bacteriophages."

The success of Phage therapy depends how we are able to give these answers.
Posted by Rodolfo Berretti at 21:55
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