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"In silico"


 From Wikipedia
If the target host* of a phage therapy treatment is not an animal the term "biocontrol" (as in phage-mediated biocontrol of bacteria) is usually employed, rather than "phage therapy".

In silico
From:"Genomics,Proteomics and Clinical Bacteriology",N.Woodford and Alan P.Johnson

Phrase that emphasizes the fact that many molecular biologists spend increasing amounts of their time in front of a computer screen, generating hypotheses that can subsequently be tested and (hopefully) confirmed in the laboratory.


Phage Therapy is influenced by:

Phage therapy is influenced by:

Country : the epidemiological situation is different from country to country in terms of circulating bacteria and bacteriophages. Example: lytic phages from Italy may be no active on the same bacteria (genus and species) isolated from another country and vice versa.
Temporariness
 Mutation rate
Phenotypical delay
Phage cocktail

My point of view

Saturday 6 February 2010

To explore Mycobacterium ulcerans by "In Silico". Step 2



*It is possible to show the genome map of Mycobacterium ulcerans by Bacmap:


Open Bacmap

Choose letter M

Choose Mycobacterium ulcerans

Open Map , now the genome map is showing.


 Remember :
COGs means Clusters of Orthologous Groups of proteins.

The genome is divided in COGs ( groups of proteins with different action).

CDS is the coding sequence or the portion of a nucleotide sequence that makes up the triplet codons that actually code for amino acids.



*By BuruList it is possible to get a lot of information on Mycobacterium ulcerans genes:

write in the window Gene name: mlsA1

open and the page is showing


Remember :

contig is a Group of cloned (copied) pieces of DNA representing overlapping regions of a particular chromosome.





Posted by Rodolfo Berretti at 13:29
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