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"In silico"


From Wikipedia
If the target host* of a phage therapy treatment is not an animal the term "biocontrol" (as in phage-mediated biocontrol of bacteria) is usually employed, rather than "phage therapy".

In silico
From:"Genomics,Proteomics and Clinical Bacteriology",N.Woodford and Alan P.Johnson

Phrase that emphasizes the fact that many molecular biologists spend increasing amounts of their time in front of a computer screen, generating hypotheses that can subsequently be tested and (hopefully) confirmed in the laboratory.


Phage Therapy is influenced by:

Phage therapy is influenced by:

Country : the epidemiological situation is different from country to country in terms of circulating bacteria and bacteriophages. Example: lytic phages from Italy may be no active on the same bacteria (genus and species) isolated from another country and vice versa.
Temporariness
Mutation rate
Phenotypical delay
Phage cocktail

My point of view

Saturday, 6 February 2010

To explore Mycobacterium ulcerans by "In Silico". Step 3



*At last, here is the
genome of Mycobacterium ulcerans

The genome presents the CDS and the respective sequences in amino acids.


*Go to
DBGET Search

Write Mycobacterium ulcerans
open and the page with information is showing.

In OMIM open NCBI for description and information on Mycobacterium ulcerans.

In REFSEQ open NC005916 or [NCBI] and see Mycobacterium ulcerans AGY99 plasmid pMUM001, complete sequence.


*Now we know its genome ( 5.6 Mb chromosome ) and its 174,155-bp plasmid.