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"In silico"


From Wikipedia
If the target host* of a phage therapy treatment is not an animal the term "biocontrol" (as in phage-mediated biocontrol of bacteria) is usually employed, rather than "phage therapy".

In silico
From:"Genomics,Proteomics and Clinical Bacteriology",N.Woodford and Alan P.Johnson

Phrase that emphasizes the fact that many molecular biologists spend increasing amounts of their time in front of a computer screen, generating hypotheses that can subsequently be tested and (hopefully) confirmed in the laboratory.


Phage Therapy is influenced by:

Phage therapy is influenced by:

Country : the epidemiological situation is different from country to country in terms of circulating bacteria and bacteriophages. Example: lytic phages from Italy may be no active on the same bacteria (genus and species) isolated from another country and vice versa.
Temporariness
Mutation rate
Phenotypical delay
Phage cocktail

My point of view

Saturday 6 February 2010

A Database about Mycobacterium ulcerans




From WHO

"Buruli ulcer is caused by a germ that mainly affects the skin but which can also affect the bone. The causative organism is called Mycobacterium ulcerans, which although different, belongs to the same family of organisms that cause leprosy and tuberculosis.

Buruli ulcer has been reported in over 30 countries with tropical and subtropical climates but it may also occur in some countries where it has not yet been recognized. Limited knowledge of the disease, its focal distribution and the fact that it affects mainly poor rural communities contribute to low reporting of cases. Progress is being made now to develop tools for early diagnosis, to understand exactly how infection is transmitted and to improve treatment".


From :

Wikipedia

WHO publications on Buruli ulcer

Course on Buruli



Department of Infectious and Parasitic Diseases Pathology - Armed Forces Institute of Pathology

Histopathologic Features of Mycobacterium ulcerans Infection

Mycobacterium ulcerans infection: factors influencing diagnostic delay

Susceptibility to development of Mycobacterium ulcerans
disease: review of possible risk factors

The Buruli Ulcer Disease Ecology Research Consortium

First Cultivation and Characterization of Mycobacterium
ulcerans from the Environment


First Isolation of Mycobacterium ulcerans from an Aquatic Environment: The End of a 60-Year Search?

Mycobacterium ulcerans in Mosquitoes Captured during Outbreak of Buruli Ulcer, Southeastern Australia

Correlation between Buruli Ulcer and Vector-borne Notifiable Diseases, Victoria, Australia

Buruli ulcer research

Buruli Ulcer Research Overview

Stop buruli