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"In silico"


From Wikipedia
If the target host* of a phage therapy treatment is not an animal the term "biocontrol" (as in phage-mediated biocontrol of bacteria) is usually employed, rather than "phage therapy".

In silico
From:"Genomics,Proteomics and Clinical Bacteriology",N.Woodford and Alan P.Johnson

Phrase that emphasizes the fact that many molecular biologists spend increasing amounts of their time in front of a computer screen, generating hypotheses that can subsequently be tested and (hopefully) confirmed in the laboratory.


Phage Therapy is influenced by:

Phage therapy is influenced by:

Country : the epidemiological situation is different from country to country in terms of circulating bacteria and bacteriophages. Example: lytic phages from Italy may be no active on the same bacteria (genus and species) isolated from another country and vice versa.
Temporariness
Mutation rate
Phenotypical delay
Phage cocktail

My point of view

Wednesday 25 November 2009

Concrete Evidence for Phage Therapy

From:

"A controlled clinical trial of a therapeutic
bacteriophage
preparation in chronic otitis
due to antibiotic-resistant
Pseudomonas aeruginosa;a preliminary report of efficacy"

UCL Ear Institute and Royal National Throat, Nose and Ear Hospital, Grays Inn Road, London, and Biocontrol Limited, BioCity, Pennyfoot Street, Nottingham, UK

Clin. Otolaryngol. 2009, 34, 349–357




The present controlled trial of bacteriophages indicates that this form of biological therapy has considerable promise.


Digital photography before (a) and after (b) in patient A0012.
Patient A0012 had a longstanding resistant otitis externa. There was swelling of the deep canal skin and ulceration in the roof of the canal adjacent to the tympanic membrane. By day 42 this had resolved and the patient was essentially symptom free.