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"In silico"


 From Wikipedia
If the target host* of a phage therapy treatment is not an animal the term "biocontrol" (as in phage-mediated biocontrol of bacteria) is usually employed, rather than "phage therapy".

In silico
From:"Genomics,Proteomics and Clinical Bacteriology",N.Woodford and Alan P.Johnson

Phrase that emphasizes the fact that many molecular biologists spend increasing amounts of their time in front of a computer screen, generating hypotheses that can subsequently be tested and (hopefully) confirmed in the laboratory.


Phage Therapy is influenced by:

Phage therapy is influenced by:

Country : the epidemiological situation is different from country to country in terms of circulating bacteria and bacteriophages. Example: lytic phages from Italy may be no active on the same bacteria (genus and species) isolated from another country and vice versa.
Temporariness
 Mutation rate
Phenotypical delay
Phage cocktail

My point of view

Saturday, 7 February 2009

Comment

I have doubts about advantages regarding a modification by molecular biology or by chemical reactions of Phages for Phage Therapy. In these cases Phage Therapy would be impracticable in a hospital because it would become an artistic work. But at times these modifications may be one solution.

I prefer a genetic modification of Phages promoted by a drastic alteration of one environmental condition all through the replication cycle of Phages inside to their hosts.
Posted by Rodolfo Berretti at 17:18
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