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"In silico"


From Wikipedia
If the target host* of a phage therapy treatment is not an animal the term "biocontrol" (as in phage-mediated biocontrol of bacteria) is usually employed, rather than "phage therapy".

In silico
From:"Genomics,Proteomics and Clinical Bacteriology",N.Woodford and Alan P.Johnson

Phrase that emphasizes the fact that many molecular biologists spend increasing amounts of their time in front of a computer screen, generating hypotheses that can subsequently be tested and (hopefully) confirmed in the laboratory.


Phage Therapy is influenced by:

Phage therapy is influenced by:

Country : the epidemiological situation is different from country to country in terms of circulating bacteria and bacteriophages. Example: lytic phages from Italy may be no active on the same bacteria (genus and species) isolated from another country and vice versa.
Temporariness
Mutation rate
Phenotypical delay
Phage cocktail

My point of view

Wednesday, 21 January 2009

Phage Therapy Works: Second part of the List

2001-BACTERIOPHAGE THERAPY.Sulakvelidze, A., Alavidze, Z. and Morris,G. J., Antimicrob. Agents Chemother.,2001, 45, 649–659.
-PHAGES AND THEIR APPLICATION AGAINST DRUG-RESISTANT BACTERIA.
N Chanishvili,T Chanishvili, M Tediashvili and PA Barrow, J Chem Technol Biotechonol 76:689-699(2001)
2002-BACTERIOPHAGE THERAPY: STALIN’S FORGOTTEN CURE. R. Stone, Science 25 October 2002:Vol. 298. no. 5594, pp. 728 - 731
2005-HUMAN VOLUNTEERS RECEIVING Escherichia coli Phage T4 ORALLY: A SAFETY TEST OF PHAGE THERAPY. A. Bruttin and H. Brüssow, Antimicrob Agents Chemother 2005, 49, 2874–2878.
2006-PHAGE THERAPY: FACTS AND FICTION.M. Skurnik, E. Strauch,International Journal of Medical Microbiology 296 (2006) 5–14
-CURRENT STATUS AND PERSPEPCTIVES OF PHAGE THERAPY.
J. BORYSOWSKI1, B.WEBER−DĄBROWSKA, A. GÓRSKI, Adv Clin Exp Med 2006, 15, 4, 575–580