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"In silico"


 From Wikipedia
If the target host* of a phage therapy treatment is not an animal the term "biocontrol" (as in phage-mediated biocontrol of bacteria) is usually employed, rather than "phage therapy".

In silico
From:"Genomics,Proteomics and Clinical Bacteriology",N.Woodford and Alan P.Johnson

Phrase that emphasizes the fact that many molecular biologists spend increasing amounts of their time in front of a computer screen, generating hypotheses that can subsequently be tested and (hopefully) confirmed in the laboratory.


Phage Therapy is influenced by:

Phage therapy is influenced by:

Country : the epidemiological situation is different from country to country in terms of circulating bacteria and bacteriophages. Example: lytic phages from Italy may be no active on the same bacteria (genus and species) isolated from another country and vice versa.
Temporariness
 Mutation rate
Phenotypical delay
Phage cocktail

My point of view

Tuesday 20 January 2009

Phage Therapy Works: First part of the List

1933- THE TREATMENT OF OSTEOMYELITIS BY BACTERIOPHAGE. Fred H. Albee, J Bone Joint Surg. Am. 1933;15:58-66.
1937-THE INFECTIOUS ORGANISM IN OSTEOMYELITIS: Part II. Ward J. Mac Neal, Bacteriophage and Serum Therapy. J Bone Joint Surg. Am. 1937;19:891-903
1970-EFFECT OF MASSIVE DOSES OF BACTERIOPHAGE ON EXCRETION OF VIBRIO,DURATION OF DIARRHOEA AND OUPUT OF STOOLS IN ACUTE CASES OF CHOLERA. Monsur, K.A., Rahman, M.A., Huq, F., Islam, M.N., Northrup, R.S.and Hirschhorn, N. , Bull World Health Organ 42: 723, 1970.
1971-CLINICAL STUDIES OF THE USE OF BACTERIOPHAGE IN THE TREATMENT OF CHOLERA. Marcuk, L.M., Nikiforov, V.N., Scerbak, J.F., Levitov, T.A., Kotljarova,R.I., Mammsina, M.S., Dovydov, S.U., Monsur, K.A., Rahman,M.A., Latif, M.A., Northrup, R.S., Cash, R.A., Huq, I., Dey, C. and Phillips RA., Bull World Health Organ 45: 77, 1971
1983-RESULTS OF BACTERIOPHAGE TREATMENT OF SUPPURATIVE BACTERIAL INFECTIONS: GENERAL EVALUATION OF THE RESULTS.S. Ślopek, I. Durlakowa, B. Weber-Dąbrowska, A. Kucharewicz-Krukowska, M. Dąbrowski, R. Bisikiewicz, Arch. Immunol. Ther. Exp., 1983, 31, 267
1987-RESULTS OF BACTERIOPHAGE TREATMENT OF SUPPURATIVE BACTERIAL INFECTIONS IN THE YEARS 1981-1986.S. Ślopek, B. Weber-Dąbrowska, M. Dąbrowski, A. Kucharewicz-Krukowska, Arch. Immunol. Ther. Exp., 1987, 35, 569
1999- PHAGE THERAPY:PAST HISTORY AND FUTURE PROSPECTS. Carlton, R. M. ,Archivum Immunologii et Therapiae Experimentalis 47:267-274.
2000-BACTERIOPHAGE THERAPY OF BACTERIAL INFECTIONS: AN UPDATE OF OUR INSTITUTE’S EXPERIENCE. B. Weber-Dąbrowska, M. Mulczyk, A. Górski, Arch. Immunol. Ther. Exp., 2000, 48, 547
Posted by Rodolfo Berretti at 20:59
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