Wednesday, 23 March 2011

Virulence factors of Mycobacterium ulcerans

From this web site

Cell wall
Antigen 85
LAM
MmaA4
PDIM
PcaA
Cellular metabolism
FadD33
Isocitrate lyase
LipF
Nitrate reductase
PanC/PanD
Heat-shock protein
HspX
Iron uptake
Mycobactin
Magnesium uptake
MgtC
Regulation
DevRS
HspR
IdeR
MprAB
PhoP
RelA
SigA
SigE
SigF
SigH
WhiB3
Secreted proteins
ESAT-6/CFP-10
Secretion system
ESX-1
ESX-5
Stress protein
AhpC
KatG
SodA
SodC
Toxin
Phospholipase C
Unclassified
Erp
HbhA
PE/PE-PGRS



Mycobacterium ulcerans Agy99



Virulence factors Related genes M. ulcerans Agy99
chromosome NC_008611 (5631606 bp)
Amino acid and purine metabolism
Glutamine synthesis glnA1 MUL_1340
Leucine synthesis leuD MUL_1969
Lysine synthesis lysA MUL_3971
Proline synthesis proC MUL_4570
Purine synthesis purC MUL_0497
Tryptophan synthesis trpD MUL_3549
Anaerobic respiration
Fused nitrate reductase narX
Nitrate reductase narG
narH
narJ
narI
Nitrate/nitrite transporter narK2
Anti-apoptosis factor
NuoG nuoG MUL_2465
Cell surface components
Exported repetitive protein erp MUL_4994
Heparin-binding hemagglutinin hbhA MUL_4543
Laminin-binding protein LBP21/Hlp -
Methyltransferase mma4 MUL_0729
Mycolic acid trans-cyclopropane synthetase cmaA2 MUL_4575
PDIM (phthiocerol dimycocerosate) and PGL (phenolic glycolipid) biosynthesis and transport fadD26 MUL_2020
fadD28 MUL_2008
ppsA MUL_2019
ppsB MUL_2018
ppsC MUL_2017
ppsD MUL_2016
ppsE MUL_2015
papA5 MUL_2011
mas MUL_2010
mmpL7 MUL_2007
ddrA MUL_2014
ddrB MUL_2013
drrC MUL_2012
pks15/1 MUL_2005
-
-
-
- MUL_2377
-
Proximal cyclopropane synthase of alpha mycolates pcaA MUL_4539
Sulfolipid-1 biosynthesis and transport stf0
papA2
papA1
pks2
mmpL8
Lipid and fatty acid metabolism
FAS-II kasB MUL_1303
Isocitrate lyase icl MUL_4536
Lipase lipF
Lipid phosphatase sapM MUL_2676
Pantothenate synthesis panC MUL_4184
panD MUL_4183
Phospholipases C plcA
plcB MUL_2799
plcC
plcD
Mammalian cell entry (mce) operons
Mce1 mce1A MUL_1062
mce1B MUL_1063
mce1C MUL_1064
mce1D MUL_1065
mce1E MUL_1066
mce1F MUL_1067
Mce2 mce2A MUL_0415
mce2B
mce2C
mce2D
mce2E
mce2F
Mce3 mce3A MUL_3918
mce3B MUL_3919
mce3C MUL_3920
mce3D MUL_3921
mce3E MUL_3922
mce3F MUL_3923
Mce4 mce4A MUL_4062
mce4B MUL_4061
mce4C MUL_4060
mce4D MUL_4059
mce4E MUL_4058
mce4F MUL_4057
Mce5 mce5A MUL_3796
mce5B MUL_3797
mce5C MUL_3798
mce5D
mce5E MUL_3800
mce5F MUL_3801
Mce6 mce6A MUL_4919
mce6B MUL_4918
mce6C MUL_4917
mce6D MUL_4916
mce6E MUL_4915
mce6F MUL_4914
Mce7 mce7A
mce7B
mce7C
mce7D
mce7E
mce7F
Mce8 mce8A
mce8B
mce8C
mce8D
mce8E
mce8F
Mce9 mce9A
mce9B
mce9C
mce9D
mce9E
mce9F
Metal uptake
ABC transporter irtA MUL_3902
irtB MUL_3901
Exochelin (smegmatis) -
Iron-dependent regulator ideR MUL_3351
Magnesium transport mgtC MUL_3069
Mycobactin mbtH MUL_3639
mbtG MUL_3640
mbtF MUL_3633
mbtE MUL_3634
mbtD MUL_3638
mbtC MUL_3637
mbtB MUL_3632
mbtA MUL_3641
mbtJ MUL_3642
mbtI MUL_3648
Regulation
(p)ppGpp synthesis and hydrolysis relA MUL_1729
DevR/S devR/dosR MUL_2423
devS MUL_2422
MprA/B mprA MUL_4701
mprB MUL_4700
PhoP/R phoP MUL_0463
phoR MUL_0464
PrrA/B prrA MUL_0248
prrB MUL_0249
Sigma A sigA/rpoV MUL_3341
Sigma E sigE MUL_4519
Sigma F sigF MUL_2640
Sigma H sigH MUL_2545
Sigma M sigM MUL_5064
WhiB3 whiB3 MUL_0895
Secreted proteins
19-kD protein lpqH MUL_4389
Alpha-crystallin hspX
Antigen 85 complex fbpA MUL_4987
fbpB MUL_2970
fbpC MUL_4793
Enhanced intracellular survival protein eis
Protein kinase G pknG MUL_2810
Secretion system
Accessory secretion factor secA2 MUL_3040
ESX-1 (ESAT-6 system-1) -
-
-
-
PE35
-
-
-
mycP1
-
ESX-1 substrates esxA
esxB
-
espA
espB
ESX-5 secretion system - MUL_3077
- MUL_3078
mycP5 MUL_3079
- MUL_3080
- MUL_3081
esxN MUL_3082
esxM MUL_3083
- MUL_3092
- MUL_3092
- MUL_3093
ESX-5 substrates PPE41
Stress adaptation
AhpC ahpC MUL_2999
Catalase-peroxidase katG MUL_2190
Cu,Zn superoxide dismutase sodC MUL_1379
Iron-cofactored SOD sodA MUL_5018