Saturday, 21 August 2010

Going in search of phages for Mycobacterium ulcerans

This is my opinion about the question.

In practice at the moment I do not have the possibility to search phages for Mycobacterium ulcerans but, if I do not have real phages, however, I can study all potential phages (prophages) inside Mycobacterium marinum and Mycobacterium ulcerans genome.


1-If I find some correlations among "prophages" of these Mycobacteria I have further evidence that M. ulcerans is originated from M.marinum.

2-
If I find some correlations between "prophages" of these Mycobacteria I have further evidence that specific phages for M. ulcerans and M.marinum could exist.



I quote the passage from:


Insights from the complete genome sequence of
Mycobacterium marinum on the evolution of Mycobacterium tuberculosis


"...and 10 putative prophages, named phiMmar01–10 (Supplemental Table 2)."




I will study these potential "prophages" one by one.