Phage therapy must be used in those conditions where the therapeutic success is elevated a priori.
Why?
a-Because Phage Therapy must maintain its best advantage : the RAPIDITY "GO, KILL and DISAPPEAR".
b- Because Phages must be Lytic and not modified by genetic engineering.
c-Because when we use the natural lytic phages in this SHORT TIME IS IMPOSSIBLE to have:
- a bacterial resistance that stops a phage attack ( 12 generations are necessary after a mutation of phage receptor in one bacterium for one phage and for this raison we use a minimum of two phages in the cocktail).
- an active immunological reaction ( two weeks are necessary).
- a bacterial resistance that stops a phage attack ( 12 generations are necessary after a mutation of phage receptor in one bacterium for one phage and for this raison we use a minimum of two phages in the cocktail).
- an active immunological reaction ( two weeks are necessary).
d-Because it is hard now to select phages and to prepare a phage cocktail by natural phages we can imagine how this will be with transformed phages.
e-Because with recombinant phages it is impossible to predict what will happen regarding the therapy and also the phage preparation is complicated and the use of these phages do not avoid the appearance of Phage Resistance.
f-For impeding the effect of the Endotoxin it is possible to use the Polimixina B.
If the abovementioned points are not adequately covered we must not use Phage Therapy .
e-Because with recombinant phages it is impossible to predict what will happen regarding the therapy and also the phage preparation is complicated and the use of these phages do not avoid the appearance of Phage Resistance.
f-For impeding the effect of the Endotoxin it is possible to use the Polimixina B.
If the abovementioned points are not adequately covered we must not use Phage Therapy .
