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"In silico"


 From Wikipedia
If the target host* of a phage therapy treatment is not an animal the term "biocontrol" (as in phage-mediated biocontrol of bacteria) is usually employed, rather than "phage therapy".

In silico
From:"Genomics,Proteomics and Clinical Bacteriology",N.Woodford and Alan P.Johnson

Phrase that emphasizes the fact that many molecular biologists spend increasing amounts of their time in front of a computer screen, generating hypotheses that can subsequently be tested and (hopefully) confirmed in the laboratory.


Phage Therapy is influenced by:

Phage therapy is influenced by:

Country : the epidemiological situation is different from country to country in terms of circulating bacteria and bacteriophages. Example: lytic phages from Italy may be no active on the same bacteria (genus and species) isolated from another country and vice versa.
Temporariness
 Mutation rate
Phenotypical delay
Phage cocktail

My point of view

Sunday, 7 February 2010

Genome identity of D29,L5,Bxz2 and TM4 mycobacteriophages

By Gepard software:


All these phages grow on Mycobacterium ulcerans and Mycobacterium smegmatis but do not grow on Mycobacterium marinum.


D29 and M.smegmatis



D29 and M.ulcerans



D29, M.ulcerans and M.smegmatis





D29 and M.marinum


D29, M.ulcerans, M.marinum and M.smegmatis



The question is why?
Posted by Rodolfo Berretti at 16:37
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