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"In silico"


From Wikipedia
If the target host* of a phage therapy treatment is not an animal the term "biocontrol" (as in phage-mediated biocontrol of bacteria) is usually employed, rather than "phage therapy".

In silico
From:"Genomics,Proteomics and Clinical Bacteriology",N.Woodford and Alan P.Johnson

Phrase that emphasizes the fact that many molecular biologists spend increasing amounts of their time in front of a computer screen, generating hypotheses that can subsequently be tested and (hopefully) confirmed in the laboratory.


Phage Therapy is influenced by:

Phage therapy is influenced by:

Country : the epidemiological situation is different from country to country in terms of circulating bacteria and bacteriophages. Example: lytic phages from Italy may be no active on the same bacteria (genus and species) isolated from another country and vice versa.
Temporariness
Mutation rate
Phenotypical delay
Phage cocktail

My point of view

Saturday, 27 February 2010

Acinetobacter phages



This is the up-to-date Acinetobacter phages list:

Acinetobacter phage 133; T4-like viruses; Myoviridae
Acinetobacter phage 205; unassigned; Leviviridae
Acinetobacter phage 531; unassigned; Siphoviridae
Acinetobacter phage A10/45; unassigned; Myoviridae
Acinetobacter phage A3/2; unassigned; Myoviridae
Acinetobacter phage A36; unassigned; Podoviridae
Acinetobacter phage BS46; unassigned; Myoviridae
Acinetobacter phage E13; unassigned; Siphoviridae
Acinetobacter phage E14; unassigned; Myoviridae
Acinetobacter phage E4; T4-like Viruses; Myoviridae

From:

EBI


NCBI

Acinetobacter phage 205; unassigned; Leviviridae ( it is the only Acinetobacter phage with complete genome).




It is necessary to be very active and to work hard because this is only the beginning.


Soothill (1992) examined the efficacy of phages in treating experimental murine infections caused by
A. baumanii, P. aeruginosa, and S.aureus. The A. baumanii and
P. aeruginosa-specific phages were isolated from sewage in Birmingham, United Kingdom, and the S.aureus-specific phage f-131 was obtained from the Hirszfeld Institute of Immunology and Experimental Therapy in Wroclaw, Poland.





Scientific work
:

"Isolation and Characterization of a Virulent Bacteriophage AB1 of Acinetobacter baumannii"

Intralytix

Intralytix products

Development of Bacteriophage Therapy for Treatment of A. baumannii Infected Wounds