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"In silico"


From Wikipedia
If the target host* of a phage therapy treatment is not an animal the term "biocontrol" (as in phage-mediated biocontrol of bacteria) is usually employed, rather than "phage therapy".

In silico
From:"Genomics,Proteomics and Clinical Bacteriology",N.Woodford and Alan P.Johnson

Phrase that emphasizes the fact that many molecular biologists spend increasing amounts of their time in front of a computer screen, generating hypotheses that can subsequently be tested and (hopefully) confirmed in the laboratory.


Phage Therapy is influenced by:

Phage therapy is influenced by:

Country : the epidemiological situation is different from country to country in terms of circulating bacteria and bacteriophages. Example: lytic phages from Italy may be no active on the same bacteria (genus and species) isolated from another country and vice versa.
Temporariness
Mutation rate
Phenotypical delay
Phage cocktail

My point of view

Saturday, 28 November 2009

Palindromes ( inverted repeats in nucleotide sequences) of: D29,L5,Bxz2 and TM4 mycobacteriophages


Palindromes of: D29


Sequence length is: 49453
Start at position: 1
End at position: 49453

Palindromes:

555 cgcttcaggcg 565

668 gcgaagtccgc 658


2469 gtggccgaga 2478

2509 caccggctct 2500


15918 ggagggggagg 15928

15957 cctccccctcc 15947


Palindromes of: L5

Sequence length is: 52337
Start at position: 1
End at position: 52337


Palindromes:

3178 ccccgagggg 3187

3228 ggggctcccc 3219


14947 ggagggggagg 14957

14986 cctccccctcc 14976


Palindromes of: BXZ2


Sequence length is: 50955
Start at position: 1
End at position: 50955



Palindromes:

226 atagtgggtgcg 237

322 tatcacccacgc 311


1047 gtcagagacc 1056

1072 cagtctctgg 1063


1338 gccccggagggg 1349

1384 cggggcctcccc 1373


15239 tggggggagggg 15250

15279 acccccctcccc 15268


25456 agcccccctc 25465

25495 tcggggggag 25486


40913 gaccacgatc 40922

40976 ctggtgctag 40967


Palindromes of: TM4


Sequence length is: 52838
Start at position: 1
End at position: 52838


Palindromes:

677 agcgtcgccg 686

727 tcgcagcggc 718


2921 cccgctgatc 2930

3017 gggcgactag 3008


6008 cgacctcggcg 6018

6067 gctggagccgc 6057


7946 gccgcactcg 7955

7991 cggcgtgagc 7982


9265 caccccgcgc 9274

9299 gtggggcgcg 9290


13926 cgagccgccg 13935

13962 gctcggcggc 13953


13962 gtcgagccag 13971

14043 cagctcggtc 14034


21762 cgcctcggcga 21772

21816 gcggagccgct 21806


26759 cagctcgcgc 26768

26802 gtcgagcgcg 26793


27354 gagaacgccg 27363

27472 ctcttgcggc 27463


30742 aaacgcccccg 30752

30778 tttgcgggggc 30768


33958 atgcacatgc 33967

34067 tacgtgtacg 34058


33963 catgcacatg 33972

34068 gtacgtgtac 34059


35315 ccgcggcgcc 35324

35356 ggcgccgcgg 35347


37378 cgtcggcgcggtcg 37391

37406 gcagccgcgccagc 37393


38621 cgtcatggtg 38630

38654 gcagtaccac 38645


40702 cgggccggtg 40711

40739 gcccggccac 40730


47393 aaacgccgca 47402

47424 tttgcggcgt 47415


48053 cgaagcaccg 48062

48094 gcttcgtggc 48085


50077 acctcaacac 50086

50107 tggagttgtg 50098


50667 acctcaacag 50676

50697 tggagttgtc 50688