1) wide spectrum of lytic activity of the bacteriophage preparation toward existing biotypes of the pathogen (achieved via polyvalent or complex nature of the preparation)
2) high virulence of single components of the preparation (i.e., separate phages composing the prep) and their high concentration (usually 10^7)
3) stability of lytic activity of the preparation with time
4) tolerance of the preparation to acidic gastric juices and, conversely, capability for easy dissolving in intestines (for preparations concerning which peroral use is anticipated; achieved usually by covering the tablets with acid-resistant coating
5) test on susceptibility of bacterial culture to bacteriophage preparation is strictly recommended. In case patient’s microflora is insensitive to phages from complex preparation,isolation of new virulent bacteriophages is needed (as well as following elevation of its activity towards this bacterial pathogen by adaptation)
6) phage therapy is considered as ONE of the components of complex treatment. In practice, phage therapy is very often combined with antibiotics and immunotherapy.
Therefore, success of bacteriophage therapy is defined by timeliness of treatment, susceptibility of patient’s microflora to the phage preparation utilized, and by optimal scheme of treatment (doses, mean of phage introduction, combination with other kinds of therapy).
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