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"In silico"


From Wikipedia
If the target host* of a phage therapy treatment is not an animal the term "biocontrol" (as in phage-mediated biocontrol of bacteria) is usually employed, rather than "phage therapy".

In silico
From:"Genomics,Proteomics and Clinical Bacteriology",N.Woodford and Alan P.Johnson

Phrase that emphasizes the fact that many molecular biologists spend increasing amounts of their time in front of a computer screen, generating hypotheses that can subsequently be tested and (hopefully) confirmed in the laboratory.


Phage Therapy is influenced by:

Phage therapy is influenced by:

Country : the epidemiological situation is different from country to country in terms of circulating bacteria and bacteriophages. Example: lytic phages from Italy may be no active on the same bacteria (genus and species) isolated from another country and vice versa.
Temporariness
Mutation rate
Phenotypical delay
Phage cocktail

My point of view

Sunday, 18 January 2009

Bacteriophages for Phage Therapy





Bacteriophages
active towards pathogenic microflora are usually acquired from the material obtained from a given patient (urine, faeces, pus, etc.). The other alternative which further gained wide spread was the isolation of virulent phage isolates from sewage waters (normally from the clinic)





Bacteriophages (Cell lysis video) available for therapy applications belong to the
Order Caudovirales divided into three families:





Myoviridae

Podoviridae

Siphoviridae

These are the lists from
ITCV(International Committee on Taxonomy of Viruses) where Order, family and genus names are sorted in:

Catalogue of Viruses

Index
A | B | C | D
E | F | G | H
I | J | K | L
M | N | O | P
Q | R | S | T
U | V | W | X


Y | Z